Nowadays, batches easily reach sizes of >1,000,000 tablets. However, only 30 tablets are used for content uniformity (CU) release testing. But there can be many more...
The UTS-Extended with integrated VisioNIR LS technology can check for these physical-chemical characteristics. In some cases, the thickness or the bizarre shape of the tablets does not allow the transmission measurement.
The solution is the possibility to switch via a multiplexer from transmission to reflection mode to enable the user to measure each available tablet on the market. For detailed homogeneity inspection requirements, the tablet can be area-scanned in reflection mode. The resulting plot is an image of the tablet showing the active pharmaceutical ingredient (API) content distribution in the tablet. On the other hand, the mean content of this multi-spot measurement can be used for an overall statement of the API content of the tablet.
From a quality point of view, the RAS (rapid area scan) measurement provides much more solid results. The reliable trend monitoring visualizes the CU prediction value of each sampled tablet. Outliers can be safely identified. The UTS-Extended is dedicated to real time release (RTR).